The semi-final of the UEFA Nations League takes place on Tuesday, with European Championships winners Italy facing Spain in Milan.
The countries battled in the semi-final of Euro 2020, with Alvaro Morata equalising with 10 minutes to go in normal time after Federico Chiesa gave Italy the lead.
Eventually, the Azzurri won 4-2 on penalties to book their place in the final against England, going on to defeat Gareth Southgate's men, again on penalties.
Roberto Mancini will have a few issues with his team selection due to some absentees in attack.
Gianluigi Donnarumma will start in goal behind a back four of Giovanni Di Lorenzo, Leonardo Bonucci, Giorgio Chiellini and Emerson Palmieri.
Leonardo Spinazzola is still out with an Achilles injury suffered at the Euros.
Nicolo Barella, Jorginho and Marco Verratti should make up the midfield three, though new Juventus man Manuel Locatelli is also pushing for a start.
Both Ciro Immobile and Andrea Belotti are injured, so Mancini must decide whether to play one of two youngsters in Moise Kean or Giacomo Raspadori, or potentially with a False Nine.
Italy v Spain: Potential XIs
With Federico Chiesa and Lorenzo Insigne on the wings, Lorenzo Pellegrini could be asked to play centrally.
For Spain, Unai Simon will likely continue in goal despite David de Gea's excellent recent form.
Cesar Azpilicueta is the most obvious option at right-back, with Pau Torres partnering Aymeric Laporte in the middle and Sergio Reguilon on the left.
With Pedri, Thiago and Marcos Llorente withdrawing from the squad due to injury, Luis Enrique may opt to give a start to Mikel Merino in midfield alongside Sergio Busquets and Koke.
17-year-old Barcelona midfielder Gavi has also been called up for the first time but it is unlikely he will be thrown in from the start.
Dani Olmo and Alvaro Morata are not in the squad because of injury so Enrique does not have many options up top.
Ferran Torres should lead the line, probably flanked by Mikel Oyarzabal and Pablo Sarabia.