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Atletico Madrid gave themselves breathing room at the top with a victory over Real Sociedad that ensured Sevilla cannot win the title.
Arsenal dragged their London rivals back into the tight battle for Champions League with victory at Stamford Bridge.
Andrea Pirlo's side got their bid for a top-four finish back on track after a disappointing defeat to Milan last time out.
The Red Devils' boss rotated his starting XI for the game against Leicester, but just two days later the superstars should return against Liverpool