Liverpool take on Manchester City on Sunday in a match that, even this early in the season, could have Premier League title ramifications.
The showdown at Anfield will feature the last two Premier League champions, with Manchester City clawing back their title from Liverpool in the 2020/21 season.
Jurgen Klopp will be without Trent Alexander-Arnold who will not be available until after the international break.
The England right-back joins Thiago and Harvey Elliott on the sidelines, which means James Milner will likely be asked to continue in the back four alongside Joel Matip, Virgil van Dijk and Andy Robertson.
Naby Keita is close to full fitness again but Klopp will continue with a midfield three of Fabinho, Jordan Henderson and Curtis Jones.
In attack, the German must also decide whether to put Roberto Firmino or Diogo Jota up top with Mohamed Salah and Sadio Mane.
For this one, Firmino might get the nod.
Pep Guardiola, meanwhile, will likely continue with his back four of Kyle Walker, Aymeric Laporte, Ruben Dias and Joao Cancelo, though John Stones is also pushing to be involved.
Gundogan is unlikely to feature which could mean a midfield three of Bernardo Silva, Rodri and Kevin De Bruyne.
Riyad Mahrez and Raheem Sterling started the loss against Paris Saint-Germain and didn't really impress, so Gabriel Jesus and Phil Foden might be asked to step in.