They have won just half of their games in the league so far, and have been poor in the Champions League, too.
On Wednesday, Arturo Vidal saw red after accosting the referee against Real Madrid, which led to a relatively comfortable 2-0 win for Los Blancos at San Siro.
Marcelo Brozovic has coronavirus, while Stefano Sensi and Matias Vecino are out injured.
Daniele Padelli and Aleksandar Kolarov are also currently in quarantine and will not feature.
That will probably lead to a midfield of Achraf Hakimi, Vidal, Nicolo Barella, Roberto Gagliardini, and potentially, Ivan Perisic, with Ashley Young replaced on the left.
Romelu Lukaku and Lautaro Martinez will start up front despite Alexis Sanchez scoring in the comeback win against Torino last week.