Barcelona travel to face Dynamo Kyiv hoping to avoid a third Champions League group stage loss this season.
The Spanish giants have been beaten 3-0 by both Bayern Munich and Benfica, and currently sit rock bottom of Group E.
They do, however, know that win in Ukraine will see them leapfrog their opponents, so three points and a good performance is critical, or an early European exit could be on the cards.
Ronald Koeman has been able to welcome Ansu Fati back into the side recently, after his long injury lay-off, and the winger scored on his first start of the season against Valencia at the weekend.
Pedri and Ousmane Dembele are both still out, but Sergio Aguero is another star who has returned from the treatment table. He made his Barcelona debut against Valencia, appearing as a late substitute.
Has the Argentine proved enough to start in midweek?
Barcelona Predicted XI
Marc-Andre ter Stegen will obviously resume duties in between the sticks, but in front of him it's a little more hazy.
Eric Garcia is suspended after receiving a red card against Benfica, while Ronaldo Araujo is injured. That means both Gerard Pique and Clement Lenglet could start, with Jordi Alba, and Sergi Roberto playing either side.
Gavi has been relied upon more and more recently, and with Pedri still injured, he will take up that role once again. He'll play alongside Sergio Busquets and Frenkie de Jong in the middle of the park.
Sergino Dest played as a right winger last time out, and with the injuries in attacking areas, he'll most likely play there again.
Unfortunately, Aguero's lack of match fitness will set him back, and it'll be Memphis Depay leading the line, with Ansu Fati cutting inside from the left flank.