Zinedine Zidane's Real Madrid side will be without several key players as they look to bounce back from their Champions League defeat to Chelsea during the week.
Los Blancos suffered a 2-0 defeat to Chelsea at Stamford Bridge, and Zidane will now look to La Liga as their only chance of winning silverware this season.
They are three points behind league leaders Atletico Madrid, but have a game in hand of their city neighbours.
Zidane will be without several players as they welcome Sevilla to Madrid, as his small squad gets put to the test as the season enters its end game.
Sergio Ramos, who didn't look fit against Chelsea, could be dropped back to the bench. Rafael Varane is also a doubt, as is Federico Valverde and Dani Carvajal.
This could force Zidane into a makeshift back line, consisting of Alvaro Odriozola, Eder Militao, Ferland Mendy and Nacho.
Fortunately for Zidane, he will be able to call upon his tried and tested midfielders Toni Kroos, Luka Modric and Casemiro.
Vinicius Jnr is another doubt for Madrid, so Eden Hazard is likely to start again. Karim Benzema and Marcos Asensio are likely to play alongside the Belgian.
Benzema is Madrid's top scorer this season, with 21 goals in 30 games in La Liga this term.