After tasting victory against Ronald Koeman's Barcelona side in El Clasico, Carlo Ancelotti will host Osasuna on Wednesday night, hoping to leapfrog Real Sociedad into top spot in Spain.
Los Blancos are now five points clear of Barcelona, and will be hoping to maintain or even extend that advantage this week.
Ancelotti's side did concede a late consolation to Sergio Aguero, and Thibaut Courtois suffered an injury scare, but the Belgian is fine, and Ancelotti will still be pleased with their performance in the derby.
Dani Carvajal returned from injury off the bench against Barcelona, and is in contention to start in midweek. Lucas Vazquez, of course, started El Clasico at right-back, but was pushed forward with the introduction of Carvajal, and managed to get on the scoresheet.
The pair may well be given a chance to play together again from the start, if Ancelotti decides to change things.
However, with the side picking up a win, he may opt for the same starting XI, with Rodrygo playing on the right wing.
How will Real Madrid line up?
Courtois is back to fitness and is ready to start in goal, with a centre-half partnership of David Alaba, who scored the opener against Barcelona, and Eder Militao in front of him.
Ferland Mendy will occupy the left-back slot, and it will most likely be Vazquez playing at right-back.
The midfield of Toni Kroos, Luka Modric, and Casemiro may be getting old, but it's still excellent, and with Federico Valverde being assessed for injury, the trio will get another chance to impress.
Rodrygo is perhaps likely to get in, but he is likely to start, with two of the most in-form players in Europe next to him: Karim Benzema and Vinicius Junior.