Manchester United boss Ole Gunnar Solskjaer will be missing three key players for this weekend's Premier League clash with Watford.
Raphael Varane, Edinson Cavani and Paul Pogba will all miss out.
The World Cup winner had been struggling with a groin injury picked up on international duty with France, while he subsequently picked up a hamstring injury. He is expected back soon, though Watford will be too early.
Cavani has a tendon injury, and Pogba will likely be out until the new year with a thigh problem.
Luke Shaw is still following concussion protocols and it is touch and go whether he will be passed fit to play, and if he isn't, Alex Telles will be given a start.
David de Gea will start in goal behind a back four of Aaron Wan-Bissaka, Victor Lindelof, Harry Maguire and Telles.
Scott McTominay suffered an illness while on international duty with Scotland but appears to have recovered which means he could partner Fred in central midfield.
Man Utd fans have been campaigning for Donny van de Beek to receive a start for a while now, but Solskjaer will probably go with the Fred-McTominay partnership again.
Jadon Sancho will be pushing hard for a start, but Solskjaer will probably go with Marcus Rashford, Mason Greenwood and Bruno Fernandes in behind lone striker Cristiano Ronaldo.