Manchester United will have to contend without first choice central defensive duo Harry Maguire and Raphael Varane when they take on Leicester on Saturday.
Maguire has been missing since the 1-0 loss against Aston Villa, and although he is close to a return, he will likely not be fit enough to feature versus the Foxes due to a limited amount of training.
Varane, meanwhile, picked up a groin injury on international duty with France.
That will force Ole Gunnar Solskjaer into selecting Eric Bailly and Victor Lindelof in the centre of the back four, though Scott McTominay is also an option, having featured in defence for Scotland against Israel.
David de Gea will start in goal, with Aaron Wan-Bissaka and Luke Shaw in the full-back roles.
With Bailly and Lindelof likely to start at the back, Solskjaer would probably have been pragmatic in his central midfield selection but with Fred not available due to travelling back from Brazil on Friday, Paul Pogba will likely be asked to play alongside Scott McTominay.
Bruno Fernandes, Jadon Sancho and Mason Greenwood will likely make up the attacking midfield three behind Cristiano Ronaldo.
Like Fred, Edinson Cavani was away in South America this week and will not play.
For the first time in the 2021/22 campaign, the Red Devils will have Marcus Rashford available, though he will likely start the match on the bench.
The England international hasn't played this season yet after recovering from shoulder surgery.