Ronald Koeman has been told he has to raise funds in order to bolster his squad at Camp Nou this season, and he has already let Ivan Rakitic leave for Sevilla, while the club are still trying to get Luis Suarez's £14m salary off their books.
And they are set to recoup a significant fee for Semedo, who had a less-than-stellar season which culminated in being humiliated by Alphonso Davies in Barca's 8-2 thumping at the hands of Bayern Munich in the Champions League.
But Wolves have been ambitious in the market so far and after spending £35m on young Portuguese talent Fabio Silva, look set to spend as much again on the 26-year-old, with a deal close to being completed.
Meanwhile Vidal is in Italy to complete his medical before joining up with Antonio Conte's side, the Chilean set to sign a two-year deal with the Milan giants.
Barcelona will be content to remove Vidal's salary from the books, two years after his arrival from Bayern Munich, while the Semedo deal gives Barca options.
They have been linked with a move for Ajax wide man Serginio Dest and have even allegedly made an approach for Norwich's Max Aarons.