The striker had been out through injury for the last several league games, but started midweek in the 3-2 win against Genoa in the Coppa Italia, and is expected to start.
Paulo Dybala is out with an injury of his own, sustained in the 3-1 win against Sassuolo, and thus Morata will replace the Argentine.
In defence, Matthjis de Ligt is missing for Juve through Covid-19, therefore club stalwart Giorgio Chiellini will replace the Dutchman at centre back.
Danilo is likely to start at right-back for the missing Juan Cuadrado. On the opposite flank, Gianluca Frabotta is expected to continue to deputise for Alex Sandro.
In midfield, Juventus are expected to recall Rodrigo Bentancur and Aaron Ramsey, both of whom were rested in the midweek cup victory against Genoa.
Arthur will likely drop to the bench, whilst Weston McKennie is still out through injury.
Adrien Rabiot and Federico Chiesa will complete the four-man midfield.
Cristiano Ronaldo will partner Morata up front.
For Inter, Antonio Conte is likely to retain most, if not all, of the starting XI that played in the entertaining 2-2 draw with Roma last weekend.
Milan Skrinriar, Stefan De Vrij and Alessandro Bastoni will occupy the three central defensive positions.
In the midfield five, Achraf Hakimi, who has scored six times already this season, will occupy the right wing-back position.
The midfield trio will likely consist of Arturo Vidal, who will play against his old club, Nicolo Barella and Marcelo Brozovic.
The only likely change is that Matteo Darmian could drop to the bench for Ashley Young.
Romelu Lukaku and Lautaro Martinez will lead the line for the Nerazzurri.
Alexis Sanchez and Christian Eriksen may makes appearances off the bench should Conte need to freshen things up.