The tie sees two of the giants of European football, and indeed two of the most successful clubs in the Champions League and European Cup, come head-to-head over two legs.
In the history of the two clubs, they have faced each other six times in competitive matches, with five of the meetings coming in the last 15 years.
Liverpool v Real Madrid: Head-to-head
|Real Madrid 3-1 Liverpool
|Real Madrid 1-0 Liverpool
|Liverpool 0-3 Real Madrid
|Liverpool 4-0 Real Madrid
|Real Madrid 0-1 Liverpool
|Liverpool 1-0 Real Madrid
In the 1980/81 edition of the European Cup, the Reds emerged victorious at the Parc des Princes with a 1-0 win, with Alan Kennedy scoring the only goal of the game in the last 10 minutes.
A lot more happened in the other final which took place in the 2017/18 campaign. Real Madrid won that one 3-1 as fans witnessed arguably the greatest goal ever scored in the final, with Gareth Bale leading up to fire a miraculous overhead kick into the top corner to seal the crown for Los Blancos.
That night was one to forget for Liverpool goalkeeper Loris Karius, who made a high-profile error.
Interestingly, both sides have won three games each and each of the three wins have come in a run.
The biggest win for either side came in the 2008/09 campaign as Liverpool won 4-0 in the last 16 at Anfield, with Steven Gerrard scoring two, and Fernando Torres and Andrea Dossena scoring one each.