The reigning champions had more than 75% of the possession and peppered the Spurs goal with shots from all angles, scoring the winning goal just before injury time via a Roberto Firmino header.
Mohamed Salah had given the Reds the lead in the first half, only for the reigning champions to be the victim of a sucker punch as Tottenham hit on the break, with Heung-min Son lashing in a superb finish 33 minutes in.
Who were the best and worst performers from both sides?
✔️ GOOD PERFORMANCE
Hugo Lloris: 8.2
One player who certainly didn't deserve to be on the losing side was Hugo Lloris, who made no less than nine saves between the sticks to continually deny Liverpool their second goal, right up until Firmino headed home from a corner.
Liverpool had 11 shots on target in total, and really should have scored more on the night, with Lloris proving a formidable barrier.
❌ BAD PERFORMANCE
Steven Bergwijn: 5.4
Tottenham had chances on the break and one of the best landed at the feet of Steven Bergwijn, who hit the inside of the post with a curled effort from the left of the box.
But otherwise he was involved in eight ground duels but won just two, while he completed just eight passes in his 76 minutes on the field.
❌ BAD PERFORMANCE
Eric Dier: 5.6
Dier had been in good form recently for Spurs, largely due to the protection he gets just ahead of him but when Liverpool breached that midfield line he was exposed, and struggled.
Despite being up against the best forward line in the league, he was not involved in a single duel and didn't win, or even attempt, a single tackle.
⭐ STAR MAN
Curtis Jones: 8.4
Firmino and Salah may have got the two vital goals for the champions, but Liverpool's best player was Curtis Jones.
With Tottenham usually sitting deeper, it was vital that possession was moved as quickly as possible in midfield, and that is how Jones positively impacted the game. He completed a quite remarkable 106/113 passes and has the third-most touches of any player in Premier League's Wednesday fixtures with 129.
He worked hard, too, making nine ball recoveries and four clearances.