During the Merseyside derby, the Dutchman's knee could be seen inverting at a gruesome angle under a ridiculous challenge from Jordan Pickford.
With his absence sure to be felt, Liverpool will have to rally at the back.
For the foreseeable future, it will probably by Joel Matip and Joe Gomez left to pick up the pieces, though Fabinho has proven he is more than capable of stepping in at centre-back if required.
For the match against Ajax, it will likely be the case that the Brazilian starts in defence, with Matip picking up an issue in the derby too.
Another victim of the derby battle was Thiago, who emerged on the wrong end of a shocking tackle from Richarlison. Any issue with the former Bayern man is not believed to be serious, but he could sit this one out which would open up a space for Naby Keita in midfield.
Alisson and Alex Oxlade-Chamberlain will once again miss out.