In the last match between the two teams, Jurgen Klopp and Frank Lampard clashed verbally on the touchline so this one already has a bit of extra spice.
With regards to transfer activity, it took Liverpool a little while to warm up to conducting business as prior to this week they had only signed backup left-back Konstantinos Tsimikas.
However, they have burst into life within the past few days with the signing of Thiago from Bayern and the soon-to-be-confirmed signing of Diogo Jota from Wolves.
Chelsea's new-look team is yet to take shake as Hakim Ziyech and Ben Chilwell are still injured, while Thiago Silva is not match fit. Christian Pulisic is still recovering from a hamstring problem, but Lampard has received positive news over the past few days that Timo Werner will be fit after suffering a dead leg against Brighton.
Jurgen Klopp, meanwhile, may feel it is a bit premature to fire Thiago into the starting XI with his transfer only confirmed on Friday. Expect a place on the bench for the Spaniard, but you never know.
Tsimikas, Alex Oxlade-Chamberlain, and Xherdan Shaqiri are all definite absentees.