Inter host Real Madrid at San Siro on Wednesday in Group D in one of the biggest matches of matchday one of the 2021-22 Champions League.

It is the second year in a row that the two teams have met in the group stages, with Madrid winning both games in the 2020-21 campaign.

Inter have a different team this season, with Simone Inzaghi succeeding Antonio Conte as manager, and key players Romelu Lukaku and Achraf Hakimi leaving.

Lukaku's replacement Edin Dzeko will lead the line, flanked by Lautaro Martinez.

The big doubt is in defence as Alessandro Bastoni struggles with a thigh problem and could be replaced by either Federico Dimarco or Danilo D'Ambrosio. Stefan De Vrij and Milian Skirinar are guarantees in the back three. Samir Handanovic will be in goal with Matteo Darmian and Ivan Perisic the wing-backs in Inzaghi's 3-5-2.

The midfield should consist of Nicolo Barella, Marcelo Brozovic and Hakan Calhanoglu, although Arturo Vidal is battling the Turkish international for his spot.

As for Real Madrid, they are without five players for the trip to Milan.

Real Madrid are without a host of players for the trip to Milan.

Marcelo, Ferland Mendy, Gareth Bale, Toni Kroos and Dani Ceballos are all absent from the squad that travelled.

Youngster Miguel Gutierrez will start at left-back for the third game in a row due to the injuries to Mendy and Marcelo.

David Alaba and Luka Jovic are in the squad, but both will be assessed before kick-off as the former is struggling with muscle overload and the latter from gastroenteritis.

Karim Benzema will lead the line for Real Madrid after scoring a hat-trick at the weekend, and he will be flanked by Eden Hazard and Vinicius Jr.

It is possible that this 4-3-3 could end up being more of a 4-4-2, as it was at times on Sunday against Celta Vigo, with Vini Jr dropping to left midfield, Federico Valverde shuffling over to right midfield and Benzema and Hazard in a front two.