Shakhtar and Atalanta will both aim to secure their first win of the Champions League campaign when they meet at the VELTINS-Arena in Gelsenkirchen.
They are on the board already, having secured draws on Matchday One.
Match Preview
Shakhtar Recent Form
Shakhtar have endured mixed fortunes this season as they currently sit third in the Ukrainian Premier League. From seven matches they have won four, drawn one and lost two, with the losses coming against Polissia and Oleksandriya.
They are unbeaten in four games, though, and that run includes the 0-0 away draw against Bologna on Matchday One.
Shakhtar Injury News
Goalkeeper Tymur Puzankov has been missing since January due to a serious knee injury and will be out a while longer.
Danylo Sikan suffered a facial injury against Bologna and has missed the last two games. It seems unlikely he'll be passed fit to play this one, though Yukhym Konoplya returned from injury in Friday's league game.
Last Shakhtar Lineup
Here's how Shakhtar lined up against Veres.
Atalanta Recent Form
Atalanta are on a poor run of form with just one with victory in their last six matches in all competitions. Indeed, they've won just two games all season which came against Lecce and Fiorentina.
In their last three, they have drawn with Arsenal in the Champions League and lost against Como and drawn with Bologna in Serie A.
Atalanta Injury News
Gianluca Scamacca and Giorgio Scalvini are out until 2025 due to serious knee injuries, while there are major doubts over Rafael Toloi, Ben Godfrey and Marco Brescianini.
Isak Hien missed the Bologna game due an abductor issue but could make it back.
Last Atalanta Lineup
Here's how Atalanta lined up against Bologna.
Shakhtar - Player To Watch
22-year-old midfielder Heorhiy Sudakov will likely be the next player to leave Shakhtar for big money and he has been in decent form, with two goals in his last two games.
Atalanta - Player To Watch
New signing Mateo Retegui has stepped up in Scamacca's absence with four goals in five Serie A starts. He hasn't scored in three games, though, so will be hoping to get back on the scoresheet on Wednesday.
Shakhtar vs Atalanta - Prediction
This may be Shakhtar's home match on paper, but due to the ongoing conflict in Ukraine, they are forced to play in Germany. The home advantage is therefore non-existent, but Atalanta don't look like themselves at all this campaign and have struggled on the road.
Scoreline prediction - Shakhtar 1-1 Atalanta
Shakhtar vs Atalanta - Betting Tips
Under 2.5 Goals Scored
- In half their matches this season, Atalanta have failed to score a single goal
- Three out of Shakhtar's last five games have ended with two goals or less scored
