Roma are set to be bought by American billionaire Dan Friedkin for €591m.
The club are currently owned by another American, James Pallotta, who took over the club in 2012 but has on occasion clashed with Roma fans, while he has seen plans to replace the Stadio Olimpico with a brand new facility scuppered by planning issues.
"We have signed the contracts tonight and, over the coming days, will now work together to complete the formal and legal process that will result in the club changing hands," Roma president Pallotta said in a statement on Thursday.
"Over the last month, Dan and Ryan Friedkin have demonstrated their total commitment to finalising this deal and taking the club forward in a positive way.
“I am sure they will be great future owners for AS Roma."
Friedkin is the CEO of Gulf States Toyota Distributors, an American franchise distributor of Toyota vehicles and parts.
The takeover will be completed without Roma having qualified for the Champions League via their league position.
However, they could make it if they manage to win the Europa League, with them set to take on Sevilla in the Round of 16 on Thursday.