Remarkably, the majority of players available to the German will have had just one, or perhaps no training sessions in preparation for the match due to their duties at international level.
PSG also have a remarkable list of injuries and suspensions which may force him into playing stars he would rather rest.
He also has the upcoming Champions League fixture against Manchester United to think about next midweek.
He may opt to give some of his star players a rest. Neymar was in magical form for Brazil over the break, recording a 10.0 FC Rating in a 5-0 win over Bolivia and a 9.7 FC Rating in a 4-2 win over Peru, with him scoring a hat-trick in the latter.
Not only has he had to travel to South America and back, but also play in Bolivia, with La Paz known for its energy-sucking high altitude.
The Brazilian will likely still play due to the huge list of absentees.
Kylian Mbappe played three matches for France over the break, but it might be a step too far to rest both him and Neymar, so he could start. If not, expect an appearance off the bench. He also didn't have nearly as long a travelling time as his Brazilian colleague.
Tuchel's hands are tied somewhat, though, as Marquinhos, Layvin Kurzawa and Angel Di Maria are all suspended, while Thilo Kehrer, Julian Draxler, Marco Verratti, Mauro Icardi, and Juan Bernat are out with injury.
Ander Herrera has tested positive for Covid, while Danilo is isolating after a contact case.
The game should present the perfect opportunity to give a debut to new signing Rafinha.