With the German Bundesliga having led the way by being the first elite league in Europe to return after the postponement of the 2019/20 campaign, La Liga will follow Thursday evening.
Unlike Germany, honours are still up for grabs in Spain including the league title, Champions League qualification, and the battle to avoid relegation.
Due to the lengthy break between matches, any analysis of actual form is largely meaningless, but before the break,Los Nervionenses were on a patchy run, and although they remained unbeaten in their last six, they won only two of those fixtures against Getafe and Osasuna respectively.
They are currently third in La Liga and although they are not involved in the title race, they are preoccupied with Champions League qualification. That is by no means a foregone conclusion either, with just five points separating them in third and Valencia in seventh, with Real Sociedad, Getafe, and Atletico Madrid sandwiched in between.
Real Betis are one of the few teams in the league who don't actually have much to play for. With their position in 12th, they are well clear of the relegation zone and would need an excellent run of form combined with various teams above them dropping points to catapult themselves into European contention.
Betis are on a horrendous run of just one victory in eight matches. However, their solitary win came in their last competitive match as they defeated Real Madrid 2-1 with goals from Sidnei and Cristian Tello.
They have won just eight matches all season; they don't score enough goals and they concede too many.
Betis' highest-rated FootballCritic player so far this season, Joaquin
For Sevilla, influential midfielder Nemanja Gudelj will miss the game due to suspension, but they could welcome back Fernando to action. The Brazilian was set to miss a large portion of the season after suffering injury, but has used the break in play to recover.
The break seems to have benefited Betis, too, as they could also welcome back two key players in William Carvalho and Andres Guardado.
LIKELY STARTING XIs
Sevilla (4-3-3): Vaclík; Navas, Kounde, Sergio Gomez, Reguilon; Jordan, Fernando, Oliver; Ocampos, En-Nesyri, Lopes
BETIS (4-2-3-1): Robles; Emerson Royal, Bartra, Mandi, Moreno; Guardado, Estrada; Fekir, Canales, Joaquin; Iglesias
PLAYER TO WATCH
The Argentine is Sevilla's top goalscorer in the league this season, and also proved to be the difference in the last El Gran Derbi.