With qualification for the knockout stage already secured following the late win against Rennes last week, the Blues boss has the opportunity to give some players a rest and others some deserved game time.
So, Lampard could opt for some rotation, but while keeping the quality there, which his squad has in abundance.
Thiago Silva has been in superb form recently but could be given a rest, with Antonio Rudiger coming into defence, with club captain Cesar Azpilicueta joining him at right-back.
Jorginho could start, potentially at the expense of Mateo Kovacic.
In attack, Lampard has a wealth of options to choose from.
After proving to be the hero in the last Champions League game, Olivier Giroud might well have earned himself a start here, with Christian Pulisic and Kai Havertz also coming in after both players featured off the bench in the 0-0 draw at home to Tottenham.
That means that Tammy Abraham, Timo Wener, and Hakim Ziyech could drop out.
Mason Mount may feature on the right this time, but will be interchangeable with Havertz.