The Portuguese star returned to the Juve starting XI against Hungarian side Ferencvaros in the Champions League following testing positive for Covid and was forced to missed several games.
Morata managed to bag two goals in the match in Budapest, taking the Spaniard up to six goals in seven games in all competitions so far.
Pirlo is expected to play a 3-4-1-2 formation, as he continues to experiment with Juve's system in order to find the right combination.
Paulo Dybala is once again expected to start on the bench for the Bianconeri, despite scoring twice in the 4-1 win on Wednesday.
Dejan Kulusevski is expected to remain on the bench, with Federico Chiesa winning that particular battle.
Giorgio Chiellini will partner Leonardo Bonucci and Danilo in a back three, with Matthijs de Ligt and Alex Sandro out until after the next international break.
Juan Cuadrado should remain on the right-hand side of midfield, with Arthur, Adrien Rabiot and Weston Mckennie expected to play in the central positions.
Wojciech Szczesny is expected to remain in goal, with Gigi Buffon on the bench.