City successfully progressed in the FA Cup during the week with an away victory over Championship side Swansea, but the win was soured slightly in the second period after Rodri was forced off after a robust challenge by Yan Dhanda.
One expected absentee is Ruben Dias, however, as he is currently ill.
Guardiola said of his defender:
"Ruben had a fever.
"He still has some problems with the stomach. That’s why he couldn’t train yesterday."
With Dias having not trained, it will likely mean a return to the starting XI in the Premier League for Aymeric Laporte, who will partner John Stones.
Fernandinho is injured, with Guardiola saying he had issues with his quad.
Where possible this weekend, the former Barcelona and Bayern head coach will likely field a similar XI to the one that humbled Liverpool last weekend.
So, Rodri should be joined in a midfield three by the in-form Ilkay Gundogan and Bernardo Silva.
Sergio Aguero isn't match fit as he continues his recovery from coronavirus isolation, but it is possible that he could make the bench.
Kevin De Bruyne will miss out, as will Nathan Ake.
The victory against Swansea was Man City's record-breaking 15th in a row in all competitions. The last team to defeat Pep Guardiola's side?
Jose Mourinho's Tottenham.