Mohamed Salah hit a hat-trick as Liverpool inflicted a humiliating 5-0 defeat on rivals Manchester United at Old Trafford.
Naby Keita and Diogo Jota put Liverpool into an early 2-0 lead before Salah continued his incredible scoring run, which has seen him find the net in 10 straight matches.
He added two more to complete a brilliant hat-trick. Substitute Paul Pogba was sent off for Man Utd, whose manager Ole Gunnar Solskjaer is now under huge pressure.
Michail Antonio scored the only goal of the game in a 1-0 victory at London Stadium, a result that takes David Moyes' team above Spurs and into fourth place.
Leicester moved into the top half of the table by winning 2-1 at Brentford.
James Maddison scored the winner on 73 minutes after Mathias Joergensen had equalised Youri Tielemans' opener.
For the fixture on Saturday, Thomas Tuchel was forced into some changes to his starting XI due to the absences or Romelu Lukaku and Timo Werner, who were both injured in the Champions League match versus Malmo during the week.
The superstar pair weren't needed, though, as the Blues scored seven through Mason Mount (hat-trick), Callum Hudson-Odoi, Reece James, Ben Chilwell and a Max Aarons own goal.
Fellow title challengers Man City knew going into the Saturday evening match against Brighton that they would not be able to leapfrog Chelsea, but they did their job emphatically, too, and won 4-1 away.
Phil Foden scored two in that one as City stay in third place at the end of the weekend.
Leed had to rely on a 94th minute penalty to earn a 1-1 draw at home against Wolves.
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