The game against the Cottages comes sandwiched between two massive games against Liverpool, with Man Utd having earned a point away from home at Anfield on Sunday in a 0-0 draw.
Next weekend, they face Liverpool again, this time in the FA Cup.
Therefore, we might see some slight rotation from the Norwegian.
Versus Liverpool, Paul Pogba played on the right of the three attacking midfielders behind the striker, and although he didn't play poorly, it didn't really work. Prior to that he had been playing on the left to much more success.
However, Solskjaer may opt to bring him back into a deeper position in midfield, with Nemanja Matic given a start.
Fred and Scott McTominay could potentially be rested for the Liverpool game.
Edinson Cavani is pushing for a start, and might come in for Anthony Martial to lead the line if Solskjaer wants to shuffle the pack slightly.
Luke Shaw has been one of United's best performers this season and was again against Liverpool, but has earned a rest, which could mean a recall to the starting XI for Alex Telles.
The only other change might see Eric Bailly come in for Victor Lindelof, but Solskjaer may just stick with the Swede alongside Harry Maguire, with Aaron Wan-Bissaka at right-back
The only players currently missing are Phil Jones, Marcos Rojo, and Brandon Williams.