The Ghanaian has missed the last few weeks due to injury in a season that has been fractured by various absences.
If he is not deemed fit enough for the Benfica game, then it will probably be this weekend's huge Premier League fixture against Leicester when he will see him return.
The Gunners will be without Rob Holding after he picked up a concussion in the 1-0 loss against Manchester City on Sunday.
David Luiz and Gabriel should return to the starting XI for European action anyway, with Hector Bellerin and Kieran Tierney on either side in the full-back roles.
Tierney only returned to the team in the first leg from injury, but with the tie balanced at 1-1, Arteta will need to go strong against the Portuguese giants.
Mohamed Elneny will probably drop out of central midfield to make way for Dani Ceballos, who will partner Granit Xhaka.
Pierre-Emerick Aubameyang will lead the line, but expect an appearance from Alexandre Lacazette off the bench at some point.