Spurs are coming off one of the most dramatic games of the Premier League season so far, as despite leading 3-0 for the majority of proceedings, they ended up drawing 3-3 against West Ham.
Gareth Bale made his second debut for the club off the bench against the Hammers, and is available for the Europa League.
However, it is unlikely the Welshman's fitness will be risked against a side that Spurs should be beating comfortably without him.
The same could be said for Harry Kane, who could be doing with a rest even with his blistering start to the season.
The likes of Dele Alli, Harry Winks, Lucas Moura, and Ben Davies will be among the starting XI alterations from Mourinho.
Japhet Tanganga and Eric Dier are still injured, which will likely mean Davinson Sanchez and Toby Alderweireld starting in defence again.
Joe Hart might be given a start in goal, while Carlos Vinicius might be given a debut, too.