The legendary Swede suffered a thigh injury against Napoli last week at the Stadio San Paolo, and was forced to leave the pitch.
Ibrahimovic is expected to be out of action for several more weeks, therefore Croatian Ante Rebic will take his place at the top of the Rossoneri front line.
Rebic also started in the same position against French side Lille in the Europa League in mid-week.
Stefano Pioli rotated his midfield for the challenge of the French side on Thursday. Sandro Tonali was brought in at the expense of Franck Kessie, however it's expected that Kessie will relciam his starting position in central midfield.
Kessie is expected to be partnered by Ismael Bennacer.
Theo Hernandez, Alessio Romangnoli, Simon Kjaer and Davide Calabria are all expected to start in defence for Milan.
In the attacking midfield positions, Belgian Alexis Saelemaekers missed out on the draw with Lille, but could return to the side in place of Spaniard Samu Castillejo on the right wing.
Brahim Diaz could also replace Jens Petter Hauge on the opposite wing. The young Norwegian started against Lille.