The German tested positive for coronavirus during the week and subsequently missed the Champions League victory against Atletico Madrid after going into self-isolation.
That could mean a place in the attacking quarter for new signing Douglas Costa, with Kingsley Coman on the opposite winger after his match-winning performance against Los Colchoneros.
Leroy Sane should be available for selection, but with him just having recovered from a knee problem, it should see the Costa preferred on this occasion.
Joshua Kimmich missed the match against Arminia last weekend to be present at the birth of his child, but returned to the team against Atletico midweek and will start in midfield alongside Joshua Kimmich.
Hans Flick has Alphonso Davies and Lucas Hernandez to choose from at left-back again, and could opt to give some minutes to the former.