The biggest news heading into the game is that talisman Neymar will miss a month of football after suffering an abductor injury following a clash with Caen's Steve Yago.
That fixture was a Coupe de France game against a Ligue 2 side, and the injury to the Brazilian now means that he'll miss first leg, and likely the second leg, of PSG's upcoming Champions League last-16 tie against Barcelona, his former club.
Since the news of the injury broke, Pochettino has been criticised for playing Neymar against the minnows in the cup with such important games on the horizon.
For the Nice game, Pablo Sarabia will likely retain his place from midweek, with Kylian Mbappe playing on the right of the front three.
Moise Kean scored the only goal of the game against Caen, but could lose his place in the starting XI to Mauro Icardi for league duties.
Keylor Navas has missed the last four games due to an abductor problem but has returned to full training this week. Still, he might not be risked ahead of the Barcelona game which means another start for Sergio Rico.
Marco Verratti, too, is back training after a hip injury suffered against Marseille last week, but, again, he might be kept fresh for the Champions League.
Marquinhos and Presnel Kimpembe should return at the heart of defence.
Julian Draxler started on the left of the attacking midfield three in the cup, but could be asked to play a more central role here.