Under previous coaches, PSG have usually played with three central midfielders in a 4-3-3, but in the last few matches they have played with an effective front four under the Argentine.
Neymar, Kylian Mbappe, and Angel Di Maria should all retain their places from the 1-0 win over Angers.
Mbappe has received criticism for his performances under Pochettino as he hasn't scored yet, but with 12 goals scored in 12 starts in Ligue 1 and 14 in all competitions, it remains a matter of time before the French superstar finds the back of the net again.
One alteration to the front four might see Mauro Icardi come in at centre-forward to replace Moise Kean. The Everton loanee started the last game against Angers but didn't impress too much as was replaced with 20 minutes to go, so Pochettino might hand his compatriot an opportunity to do better.
The match winner versus Angers was Layvin Kurzawa and although he collected a small injury in the game, he is believed to be fit enough to feature on Friday.
With a clean sheet secured in that fixture, Pochettino will likely stick with Alessandro Florenzi, Abdou Diallo, and Marquinhos in defence.
Marco Verratti and Leandro Paredes should keep their places in the two-man midfield.
Thilo Kehrer and Colin Dagba have tested positive for coronavirus and will not feature.
Pochettino himself is currently isolating, too, and will not be able to coach the team from the sideline.