Spurs have been given a favourable draw for the last 16, and so we can expect star players like Harry Kane and Heung-min Son to be given a rest.
In terms of injuries, only Giovani Lo Celso is unavailable after picking up a back problem, while Joe Rodon can't feature as he was not included in the original Europa League squad.
Tottenham have the North London derby to think about this weekend, so that will give Mourinho even more cause to switch things around from the Crystal Palace game, which his side won 4-1 thanks to two goals from Kane and two goals from Gareth Bale.
Hugo Lloris will start in goal, with Eric Dier and Ben Davies coming into the defence alongside Matt Doherty and Davinson Sanchez, with Toby Alderweireld and Sergio Reguilon dropping to the bench.
Tanguy Ndombele didn't start versus Palace so will likely come into the starting XI in central midfield, with Moussa Sissoko earning a start, too. That will mean Harry Winks and Pierre-Emile Hojbjerg sitting out.
Kane, Bale and Son are all playing superbly at the moment so could all be rested with the Arsenal game in mind, with Tottenham knowing that they can come off the bench or start in the second leg if things aren't going their way.
That will allow Carlos Vinicius, Dele Alli, and Erik Lamela to make the starting line-up after being subs against Palace.
Steven Bergwijn and Lucas Moura will be competing for a start on the left, and Mourinho will likely opt for the former as he was also on the bench versus Palace.