With Ansu Fati out for up to four months and Barca still decided what to do with the inconsistent Ousmane Dembele, it was widely considered that the Camp Nou club would come back for Depay.
Ronald Koeman was keen to sign him in the summer but the finances of the Catalan giants meant that they were unable to get a deal done despite OL's desire at the time to agree terms.
"I was the first to say that he would not leave for Barcelona. Nobody listened to me at the time during the window because everyone thought that he would leave. We absolutely have to succeed this season.
"We started badly, but we have the capacity to do better, so he will stay.”
Lyon started the season in poor form but have bounced back in recent matches and Depay, who missed most of last season with a serious cruciate injury, has looked back to his best.
But the news will come as another blow to Ronald Koeman who, as well as Fati's injury, has Philippe Coutinho also crocked while Lionel Messi is free to negotiate terms with other teams from January should he wish to leave.