The Red Devils are no strangers to Wales, having faced them in qualification before, as well as the quarter finals of Euro 2016, when Chris Coleman's side pulled off a historic upset.
Roberto Martinez may be without a few key players for this game in Leuven, but he has also received a timely boost this week.
Eden Hazard is obviously a huge miss for Belgium here, as his injury nightmares at Real Madrid continue, but his brother Thorgan should play. Axel Witsel is also missing, robbing Martinez of some much-needed craft and energy in midfield.
The latter's Leicester City teammate Timothy Castagne is likely to start at wing-back, with Toby Alderweireld, Jason Denayer and Jan Vertonghen playing as part of a back three.
The big news is Romelu Lukaku's availability. Despite a COVID-19 outbreak at Inter, he has joined up with the squad after testing negative.