The Croatian is still suffering from a hamstring problem and will likely not be risked against the Hammers with Champions League fixtures against Real Madrid on the horizon.
During the week, Thomas Tuchel made a few alterations to his side for the visit of Brighton, which ended up finishing in a boring 0-0 stalemate at Stamford Bridge.
All the players on the pitch would undoubtedly have been impacted by the news of the Super League going on in the background, however, as Stamford Bridge was met with protesting fans.
Both Chelsea and Brighton were forced to take to the pitch without really knowing what was happening in the world of football around them, and you could tell, as it proved to be a drab affair.
Thiago Silva, Cesar Azpilicueta and Ben Chilwell were rested for that one so they can expect a recall to the starting XI against West Ham, with Kurt Zouma, Andreas Christensen and Marcos Alonso all dropping out.
With Kovacic still injured that should present an opportunity for N'Golo Kante to come into midfield to partner Jorginho.
That will mean Mason Mount potentially moving higher up the pitch, with Hakim Ziyech making way.
Kepa Arrizabalaga has started the last two games, but we could see Edouard Mendy brought back into the starting XI.