Jose Mourinho is expected to totally revamp his starting XI following their catastrophic exit from the Europa League at the hands of Dinamo Zagreb on Thursday
The Croatian side managed to overturn a two-goal deficit at home to win the tie 3-0 on aggregate, dumping Mourinho's side out on the process.
Following the game, Mourinho was highly critical of his players, bemoaning a 'lack of professionalism' from some of his players.
Hugo Lloris is one of the few player expected to retain their place in the team, and will continue in goal for Spurs.
Lloris will be supported by Matt Doherty, Davinson Sanchez, Toby Alderweireld and Sergio Reguilon. Sanchez is expected to be the only survivor of the defensive horror-show in Zagreb
In midfield, Pierre-Emile Hojbjerg is expected to return after missing out on the midweek game. He will be partnered in the midfield two by Tanguy Ndombele, with Harry Winks dropping down to the bench.
In the attacking positions, only Lucas Moura emerged with any credit from the Zagreb debacle, and will likely keep his place in the starting XI. He will be joined by Gareth Bale and Giovanni Lo Celso.
Heung-min Son is likely to miss out due to a hamstring injury, and Erik Lamela is suspended after getting sent off in the north London derby last week.