This is a game of contrasting fortunes between Tottenham and Manchester United.
Whilst the home side are in a dire run of form, and confidence, their visitors to the Tottenham Hotspur Stadium are on a tremendous run of form.
Both sides are expected to make changes, especially Ole Solskjaer's side, owing to their midweek game against Granada in the Europa League.
Jose Mourinho has defensive problems, and will likely start with a makeshift back four.
Confusion surrounds the status of Toby Alderweireld, and it's unknown if the Belgian will start. If not, he will likely be replaced by Japhet Tanganga in centre back. Tanganga is likely to be accompanied by Davinson Sanchez.
Matt Doherty and Ben Davies are sidelined, so full-backs will be Sergio Reguilon and Joe Rodon.
Pierre-Emile Hojbjerg will be partnered in the midfield by Tanguy Ndombele and Giovanni Lo Celso in a three-man midfield.
In the attacking positions, Lucas Moura and Heung-min Son are expected to start, and supply support for Harry Kane, who has made the headlines going into the game, with it being reported that he will leave the club should they not make Champions League football.
For Manchester Utd, meanwhile, confidence couldn't be higher going into this fixture.
They have one foot into the semi final of the Europa League, following their away win in Spain, and boss Solskjaer has very little injury worries.
Anthony Martial, Phil Jones and Eric Bailly are all confirmed to be out with injuries.
David De Gea started in the 2-0 win against Granada, but it's unsure if he will retain his place in the United goal. Dean Henderson may win back his place.
In defence, Solskjaer is likely to utilise a back four, with Aaron Wan-Bissaka, Victor Lindelof and Harry Maguire all slated to start. Shaw will start should he pass a fitness test.
In midfield, Fred is likely to return to the fold, and could be joined by Scott McTominay and Pogba, should he recover from his injury.
In attack, Solskjaer is reportedly undecided about whether to start Edinson Cavani, owing to the former Napoli and PSG striker's lack of form as of late. Cavani will most likely drop to the bench for the game.