The Welshman has been in and out of the Bianconeri side this season, and wasn't best pleased about being substituted against Fiorentina in their 3-0 defeat just before the Christmas break.
However coach Andrea Pirlo is expected to give Ramsey another chance.
Pirlo is expected to utilise a 4-4-2 against the Zebrette. Matthjis de Ligt and Leonardo Bonucci will start at centre back, with Alex Sandro and Danilo occupying the flanks, with the latter coming in for Juan Cuadrado after the Colombian received a red card in the defeat to Fiorentina.
In midfield, Ramsey will be utilised on the right of a four, but he'll be given license to roam centrally and in behind both Cristiano Ronaldo and Alvaro Morata.
Federico Chiesa will play on the other flank, with Rodrigo Bentancur and Weston McKennie in the middle.
Morata and Ronaldo will once again start up front together. The pair have netted 16 goals in Serie A this season, and will need to keep scoring if the club have any ambition to retain their domestic dominance.
Expect Paulo Dybala to come off the bench should things not be going to plan for Pirlo's men.