Ole Gunnar Solskjaer's Manchester United could be without several key players as they make the trip down to Southampton on Sunday.
The Red Devils enjoyed a 4-1 win over Turkish outfit Istanbul Basakehir in the Champions League on Tuesday night.
It's thought that Solskjaer will retain most of the same starting XI that featured in the win that saw his side top their group with two games left.
Against Basakehir, Edinson Cavani start as the sole striker for United, but it's thought that Frenchman Anthony Martial will return to the starting XI in place of the Uruguayan.
Martial is likely to be supported by a trio of Marcus Rashford, Mason Greenwood and Bruno Fernandes, who is United's top scorer in the league this campaign, with six strikes.
Fred and Donny Van de Beek are expected to start in central midfield, with the latter receiving only his first league start of the season. The Dutchman has only played 85 minutes of Premier League football since signing from Ajax last summer.
In defence, Harry Maguire will be partnered by Axel Tuanzebe. Alex Telles will start on the left, whilst Wan-Bissaka could start, should he pass a fitness test. If he fails to start, Daniel James could play in his place.