Pep Guardiola's side are already in the League Cup final, while they have progressed in the Champions League and currently lead the Premier League.
The match versus Championship side Swansea comes at a time when City are looking irresistible.
Since the draw against West Brom in the middle of December, the Premier League leaders have won 14 matches in a row in all competitions.
At the weekend, they secured a statement victory against Liverpool, humbling the defending league champions with a 4-1 away win.
Though Guardiola will be keen to keep momentum going with progression in the FA Cup, there will be changes made as he keeps his stars fresh to fight on four fronts.
Zack Steffen will likely be given a start in goal with Ederson dropping to the bench, while Aymeric Laporte, Eric Garcia, Benjamin Mendy, and Kyle Walker should return to the starting XI.
Walker missed the game against Liverpool with injury, but is believed to be fit enough to feature in the cup.
Fernandinho is a certain starter in midfield which will likely mean a rest for Ilkay Gundogan or Rodri, probably the latter.
Sergio Aguero is back in training after his coronavirus isolation but is likely not match fit, though he could make an appearance from the bench.
Nathan Ake and Kevin De Bruyne are continued absentees.