This fixture has traditionally featured plenty of goals and it will be interesting to see how Arteta's new side copes with the threat of the champions.
For Klopp, much will depend on the fitness of goalkeeper Alisson, who has an unknown issue but is a doubt for the match, If he doesn't make it, Adrian will deputise.
Thiago Alcantara is also a doubt after picking up a knock having only made his debut in the second half against Chelsea last week, while captain Jordan Henderson is definitely out. Joe Gomez has however recovered and will likely start, with Fabinho moving back into his normal slot in midfield.
Klopp praised the performances of Naby Keita and he is almost certain to start, while the front three of Roberto Firmino, Mo Salah and Sadio Mane are all available.
For Arsenal, Arteta's starting XIs have been a little more difficult to predict as he looks to find his best team.
With David Luiz returning from a neck injury in midweek he could replace Rob Holding in the back three, while Arteta will also be hoping that Kieran Tierney has suitably recovered to play on the left, with Gabriel in between.
Ahead of him Dani Ceballos and Granit Xhaka is the likely partnership in midfield, but don't rule out Mo Elneny playing to offer a little more stability than the more attack-minded Ceballos.
On the flanks Ainsley Maitland-Niles could play on the left to provide more defensive stability, allowing Hector Bellerin to slot in on the right.
Further ahead Pierre-Emerick Aubameyang will feature from the left with Alexandre Lacazette through the middle, and on the right Willian will likely get the nod ahead of Nicolas Pepe.