Last season, the Bianconeri weren't at their best under Maurizio Sarri, with Inter and Lazio maintaining a title challenge for the majority of the campaign, but they still won their ninth championship in a row.
They are going for 10-in-a-row in 2020/21 under a new boss - club legend Andrea Pirlo. The World Cup winner does have a few selection headaches heading into the game, as he is without Matthijs de Ligt after the Dutchman had shoulder surgery, while Alex Sandro is a doubt after collecting an injury in training.
Federico Bernardeschi picked up a knock on international duty and should miss out also. Perhaps crucially, Paulo Dybala is still out, too, with a thigh issue.
On the transfer front, Juve have completed the signings of Arthur from Barcelona and Weston McKennie from Schalke.
However, Pirlo remains in the hunt for another No. 9 to partner Cristiano Ronaldo in attack, with Luis Suarez and Edin Dzeko both continually linked with a move to Turin.
Expect Dejan Kulusevski to feature alongside CR7 for this opener.