Milan will be hoping to bounce back following their crushing 3-0 defeat to Inter in the Derby della Madonnina last weekend as they face another tough game against fourth-placed Roma.
Milan seeded top spot in Serie A to their city rivals, but made it through to the Round of 16 in the Europa League following a slender 3-3 draw with Red Star Belgrade, winning on away goals.
Coach Stefano Pioli made several changes for the midweek clash, and is expected to make more ahead of the Sunday night meeting with Roma.
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Milan coach Sfefano Pioli has no major absences through injury. Gianluigi Donnarumma will start in goal for the Rossoneri. Fikayo Tomori, who played in midweek against Red Star, could retain his place due to the poor performance of club captain Alessio Romagnoli against Inter last weekend. He could start alongside Simon Kjaer. Theo Hernandez and Davide Calabria will occupy the two full-back positions.
In midfield, Ismael Bennacer is ready to return, according to Pioli. Bennacer could start ahead of Sandro Tonali, another who came in for criticism in the aftermath of the derby defeat. If Bennacer isn't fit to start from the beginning, then Tonali could partner Franck Kessie in the middle.
Alexis Saelemaekers will be expected to start on the right-hand side. Hakan Calhanoglu will play behind the central striker, with Ante Rebic on the opposite side.
Mario Mandzukic missed the game against Belgrade, and could make the subs bench. Meanwhile, Zlatan Ibrahimovic was rested for the game entirely, but is expected to lead the line for the Rossoneri.
Roma are going into this game in a good run of form.
Fonseca's men swatted Portuguese side Braga aside to advance to the Round of 16 in the Europa League.
Fonseca is taking the competition quite seriously, and picked a strong team for the midweek game.
Pau Lopez will continue in goal for the Giallorossi. In defence, Fonseca looks likely to start with Gianluca Mancini, Juan Jesus and Bryan Cristante.
In the midfield four, Rick Karsdorp and Leonardo Spinazzola will play as the wing-backs on either side, with Spaniard Gonzalo Villar and Joran Veretout in the central positions.
Henrikh Mkhitaryan and Lorenzo Pellegrini will play as two attacking midfielders, behind the main striker, Borja Mayoral.
Edin Dzeko, who had fallen out with Fonseca earlier in the season, could come off the bench should needed.
Predicted line-ups: Milan v Roma
Zlatan Ibrahimovic 
Edin Džeko 
Fikayo Tomori 
Milan 
Roma 
