Both nations boast 10 points after their first four games. They are flawless against Croatia and Sweden, while the previous match between the two ended in a 1-1 draw in Paris.
The return game is set to go a long way to deciding the identity of the country that will progress to the Nations League Finals, and indeed, should there be a winner, they cannot be caught by their rivals.
France have suffered a couple of significant offensive blows in the run up to this match. Wissam Ben Yedder was forced to withdraw from the squad after suffering a Covid-19 infection, while Kylian Mbappe failed to train on Friday and will not take any part in the match.
Defeated 2-0 by Finland in a midweek friendly, France are expected to make changes to their starting XI. Indeed, Didier Deschamps is primed to make as many as nine alterations from the team that started that game and is set to change the system back to the more familiar 4-3-3.
Chelsea forward Olivier Giroud and Manchester United’s Paul Pogba are set to be the survivors, although there is no guarantee that the latter will start after a poor run of form.
Flanking Giroud in attack will be Antoine Griezmann and Kingsley Coman. Griezmann will, for the sake of the teamsheet, be deployed on the right but is liable to be given the licence to drop deep into a No.10 role at times, giving France the capacity to go into a diamond.
Goalkeepers: Costil (Bordeaux), Mandanda (Marseille), Maignan (Lille), Lloris (Tottenham)
Midfielders: Pogba (Manchester United), Tolisso (Bayern Munich), Kante (Chelsea), Rabiot (Juventus), Nzonzi (Rennes), Sissoko (Tottenham)
Forwards: Griezmann (Barcelona), Giroud (Chelsea), Martial (Manchester United), Coman (Bayern Munich), Thuram (Borussia Monchengladbach), Mbappe (PSG)
The debate in their squad, however, comes with regards who plays with the Juventus star. Joao Felix should be given the nod for one spot, while Diogo Jota and Bernardo Silva will squabble over the other.
Goalkeepers: Patricio (Wolves), Lopez (Lyon), Rui Silva (Granada)
Defenders: Nelson Semedo (Wolves), Ruben Semedo (Olympiacos), Dias (Manchester City), Duarte (Granada), Fonte (Lille), Mario Rui (Napoli), Cancelo (Manchester City), Guerreiro (Dortmund)
Midfielders: Moutinho (Wolves), Bernardo Silva (Manchester City), Fernandes (Manchester United), Danilo (PSG), Carvalho (Betis), Oliveira (Porto), Sanches (Lille), Neves (Wolves)
Forwards: Ronaldo (Juventus), Paulinho (Braga), Trincao (Barcelona), Pedro Neto (Wolves), Jota (Liverpool), Joao Felix (Atletico Madrid)