Mikel Arteta's side were crushed by Villa in their last outing, and Arteta will hope to make it right following the international break.
The Gunners have lost three out of their last four encounters in the Premier League, and they will want to stop the rut against Marcelo Bielsa's side.
Arteta will be without Thomas Partey and Mohamed Elneny for the game at Elland Road.
Dani Ceballos, who was reportedly involved in a training ground fracas with David Luiz this week, is expected to start in midfield, alongside Granit Xhaka.
Arsenal's long-term absentees Calum Chambers, Gabriel Martinelli and Pablo Mari are all still unavailable, but could soon be returning to action this side of Christmas.
Nicolas Pepe could replace Willian on the right wing, as the Brazilian was disciplined by the club for flying to Dubai during the international break without Arsenal's permission.
Pierre-Emerick Aubameyang will be hoping to get on the scoresheet, as the Gabon international has been struggling as of late to find the back of the net. Aubameyang has only scored twice in the league so far this season.
Alexander Lacazette is expected to start as the central striker, but the French forward is also struggling in front of goal, with only three to his name.