Andrea Pirlo's men are currently sitting in third position in the top-flight standings, 10 points behind league-leaders Inter, albeit with a game in hand.
The Old Lady scored three second-half goals in midweek to see off Spezia, keeping the pressure on Antonio Conte's side, and they'll be hoping to keep that momentum going on Saturday.
Juve are aiming to win their 10th Scudetto in a row this season, but their struggles under new boss Pirlo has allowed the San Siro outfit to steal a march on Cristiano Ronaldo and co.
Only the three points will do when Simeone Inzaghi brings his stuttering side to the Allianz Stadium, as anything less could all but end Juve's chances of retaining the title.
Former Arsenal goalkeeper Wojciech Szczesny has been solid between the sticks for Juventus this season and is set to earn his 20th league start of the season.
A back four made up of Alex Sandro, Matthijs de Ligt, Merih Demiral and Danilo is likely to feature in front of the Poland international due to injuries to Giorgio Chiellini and Leonardo Bonucci, while Gianluca Frabotta is suspended.
Summer-signing Federico Chiesa has settled into life with the reigning champions well and could form a part midfield four with Adrien Rabiot, Rodrigo Bentancur and Weston McKennie, who has just signed on a permanent deal after impressing on loan.
In attack, the ever-green Ronaldo is likely to be partnered by the highly-rated youngster Dejan Kulusevski, with the 20-year-old Swede continuing to search for his first league goal since December.