Fred enjoyed one of his best games in a Manchester United shirt as they comfortably defeated Club Brugge 5-0, with him scoring two and assisting another.
His assist came first four minutes before the break as he found himself in a great position inside the box in the left channel which allowed him to lay a pass off for Scott McTominay to score.
In the second half it was all about him, though, as he scored his first with a close range finish before scoring arguably the goal of the game with a delightful left-footed strike into the left corner from the edge of the area in injury time.
Even if you were to disregard his goal contributions he still had an excellent evening. He touched the ball 113 times and completed a superb 85/93 attempted passes.
He played a part in all three goals for the German side. His two assists came via bursting runs into the box from midfield, which he did the entire game, as he slid a pass to Lucas Alario and then Kerem Demirbay for their respective strikes.
It then became time for him to be the beneficiary of some good work by someone else, as Moussa Diaby unselfishly passed sideways to him after a melee involving the opposition goalkeeper and some defenders for the Leverkusen captain to convert into the empty net.
He only misplaced four out of 51 attempted passes on the night, with 12 of the successful ones being sent into the final third.
Jonathan Calleri, remarkably, only completed seven passes in the 90 minutes, but who needs passes when you score a hat-trick?
He netted all three of his side's goals on the night, with the first being scored from a yard out and the second coming from the penalty spot.
The third, to make it 3-2, was a towering header into the bottom corner but the damage had been done in the first leg for the hosts.
He grabbed a deserved goal to make it 2-2 with 10 minutes to go after finishing a lovely move following a quickly taken throw-in from the Premier League side, with him eventually scoring free at the back post.
The best work arguably came before that, though.
He won 10/17 duels, 100% of his tackles, and 4/6 aerial duels, while he also made nine ball recoveries.
Pizzi put in a talismanic performance for Benfica as they drew 3-3 with Shakhtar, only to unfortunately for them, go out on away goals.
After being 2-1 down from the first leg, he single handedly hauled Benfica back into contention by contributing to two goals in the first half.
The first was his own, and it was an absolutely beauty as he drifted into the centre via the left channel unopposed before guiding a lovely, curled right-footed effort into the bottom corner.
After an own goal from Ruben Dias made it 1-1, he would help give Benfica the lead again with a corner straight on to the head of Dias to redeem himself.
He was always looking to set up team-mates where possible, sending 12 crosses into the box and 23 passes into the final third.