Many of these goals have powered the club on to glory with numerous La Liga titles and Champions League titles won with the Argentine at the club, as well as a record six Ballon d'Or awards individually.
When he broke through at Barcelona as a 16-year-old, Messi was primarily deployed on the right wing in order to cut inside on his cultured left foot.
As his career has gone one, he has moved into the centre-forward position in a False 9 role, and then into a more conventional number 10 role, while in his later years he has dropped deeper and deeper in order to pick up possession and impact proceedings.
He has scored goals from nearly everyone, as shown by the graphic below, created by FootballCritic contributor Marius Fischer.
Here it is! Goal map of all 648 Messi goals for FC Barcelona.— Marius Fischer (@Gegenpressing91) January 11, 2021
Plotted according to the FIRST touch he made (in a dribbling for example) before scoring. Freekicks are white.
The ones in & around the box - ok. But the amount of times he started nearly at the halfway line. ABSURD! pic.twitter.com/11p492Mr6K
What we can see from the above is every single Messi goal for Barcelona, with the points indicating where his first touch was taken in the particular move that led him to finding the back of the net.
Naturally, as a prolific goalscorer the majority of the Argentine's goals come within the penalty area, or at least with his first touch coming inside the penalty area.
However, as a master dribbler, he is also famed for embarking on remarkable dribbles, ghosting in between opposition players before either making his way into the box to score or rifling in a strike from range.
Interestingly, there is only one point which is placed inside his own half, and it belongs to arguably the most famous goal of his career.
Picking up the ball on the right wing against Getafe, he injects a ridiculous change of speed into his dribble, continually bursting forward while remaining in complete control of the ball.
He eventually takes it past numerous opposition players before making his way into the box to round the keeper and score.
When it happened in the 2006/07 campaign, it made everyone stand up and take notice, mainly because it was eerily similar to another famous goal scored by Diego Maradona against England in the World Cup.
It featured the same low centre of gravity, the same master over the ball, the same genius.
FootballCritic has previously listed and ranked Messi's greatest ever goals which you can view here.
You can follow Marius Fischer on Twitter @@Gegenpressing91