In the first leg between the sides a week ago, Spurs ran out comfortable 4-1 winners thanks to goals from Heung-min Son, Gareth Bale, Lucas Moura, and Carlos Vinicius.
Several first team players were rested for that one and with Tottenham already having one foot in the last 16, Mourinho will ring the changes from the weekend loss versus West Ham.
Harry Kane won't feature from the start which will present another opportunity for Vinicius, who already has four goals in the competition this season.
Son will likely be the player to drop out of the starting XI for the Benfica loanee.
Lucas Moura has scored two goals in two games but Mourinho might then want to keep him for Premier League action, which could mean a start for Steven Bergwijn in the attacking midfield trio alongside Dele Alli and, potentially, Erik Lamela.
Bale started the first leg but it appears he is going to be utilised in the league more going forward, and with his manager claiming he can't play three times in a week, he might be rested with the tie basically done and dusted.
Harry Winks and Moussa Sissoko will start in the middle of midfield again.
Spurs aren't blessed with too many options at the back currently but Japhet Tanganga could come in for Eric Dier in the centre of the defence.
Giovani Lo Celso and Serge Aurier remain the only absentees.