Andrea Pirlo could be set to hand Matthijs de Ligt his first start of the 2020/21 campaign when Juventus take on Cagliari on Saturday.
The former Ajax defender is yet to make an appearance in Serie A or any other competition this term, but is reportedly back fighting fit and ready to feature for Juve.
Although Pirlo may not have wanted to throw him back into the starting line-up right away, he may be forced to, as both Giorgio Chiellini and Leonardo Bonucci are missing for this one.
That could mean a back three of De Ligt, Merih Demiral, and Danilo.
Alex Sandro will likely return to the squad, but in contrast to De Ligt, Pirlo might decide against a start for the Brazilian right away.
Aaron Ramsey is still absent but could be available for the Ferencvaros game during the week.
Federico Chiesa suffered a knock while on international duty with Italy, but took part in full training with his team-mates on Thursday and should be available for selection. Adrien Rabiot might not be fully fit after a similar issue, however.
Paulo Dybala did not play for Argentina over the international break after suffering from a urinary infection.
It wasn't looking likely that he would be able to feature against Cagliari, but like Chiesa, he took part in full training on Thursday, so might come off the bench if needed.
Cristiano Ronaldo will, of course, start up top, perhaps in a triumvirate with Dejan Kulusevski and Alvaro Morata.